Yes! For example, if you are hoping that a student reads along with a book being presented in a YouTube video, you could make an assignment like this:
With instructions on how to access the video, like this:
And include the settings of recording their desktop with their microphone, like this:
Then, a student can open the assignment, click on the YouTube link, mute the video, and read along to the book. Here's my recording:
And here's what the assignment looks like as a student: https://app.screencastify.com/record/_gnwDDz2hJ3_dBelHe